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We have developed 8 microarrays based on the tuberculosis proteome library for functional studies:
|
Name |
Description |
Proteins of this type in MTB |
Proteins of this type on chip |
Coverage |
Reference |
|
MTB secreted proteins |
Secreted proteins may be associated with infection, virulence or immune stimulation. |
257 |
231 |
90% |
Malen et al., Proteomics, 2007 |
|
MTB Serine/threonine protein kinases |
Kinases are enzymes that transfer phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation. |
11 |
11 |
100% |
Cole et al., Nature, 1998 |
|
MTB transcription factors |
A transcription factor is a protein that binds to the 5'-end of a DNA sequence, thereby controlling the rate of transcription of genetic information from DNA to mRNA. |
185 |
181 |
98% |
Cole et al., Nature, 1998 |
|
MTB lipid metabolism related proteins |
Proteins involved in lipid metabolism. |
272 |
243 |
89% |
Cole et al., Nature, 1998 |
|
MTB metabolic pathway proteins |
Proteins involved in metabolism (other than lipid metabolism), e.g. sugar, ketone, or acid metabolism. |
290 |
269 |
93% |
Cole et al., Nature, 1998 |
|
MTB drug resistance related proteins |
MTB proteins which may be involved in natural drug resistance. |
85 |
76 |
89% |
Zhang et al., Nature Genetics, 2013 |
|
MTB PE/PPE family proteins |
Two major protein families containing proteins with sequences similar to PE or PPE proteins. May be involved in immune responses etc. |
168 |
122 |
73% |
Cole et al., Nature, 1998 |
|
MTB virulence factor proteins |
Proteins involved in MTB toxicity. |
205 |
184 |
90% |
Forrellad et al., Virulence, 2013 |